Quick details

Tibolone (brand name Livial), also known as 7α-methylnoretynodrel, works by mimicking the activity of the female sex hormones, oestrogen and progesterone. It also has some male hormone (androgen) effects. Tibolone helps to restore the balance of female hormones in women who have a lack of oestrogen; it helps to ease symptoms such as hot flushes and night sweats.

Tibolone is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women. Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist mainly at estrogen receptors, with a preference for ER alpha. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile. It has also been investigated as a possible treatment for female sexual dysfunction.

Tibolone is also prescribed to help prevent osteoporosis (bone loss). It is only suitable for women who have been through the menopause, and providing there have been at least 12 months since the last natural period. It is prescribed when other, more preferred, treatments are not suitable.

1.Before you start taking the tablets, read the manufacturer's printed information leaflet from inside your

pack. The manufacturer's leaflet will give you more information about tibolone and a full list of the

side-effects which you may experience from taking it.

2.Take one 2.5 mg tablet every day. You may take at whatever time of day you find easiest to remember,

but try to take your doses at the same time of day, each day. You can take the tablets before or after

meals. You may find it helps to swallow the tablet with a drink of water.

3.If you forget to take a dose, take it as soon as you remember unless you are more than 12 hours late. If

you are more than 12 hours late, leave out the forgotten dose and take your next tablet at the usual time.

Do not take two tablets together to make up for a missed dose.

1. One tablet should be taken once a day, at the same time each day.
2. The tablet can be taken either with or without food. Swallow it with a drink.
3. If you forget to take your tablet at your usual time and it is less than 12 hours late, take it as soon as you remember. If it is more than 12 hours late, leave out the missed dose and take your next dose as usual when it is due. Do not take a double dose to make up for a missed dose.
4. Missing a dose increases the risk of experiencing vaginal bleeding or spotting.
5. Keep taking this medicine every day until your doctor tells you to stop. Your doctor will prescribe the lowest dose to treat your symptoms for as short a time as necessary.